The MaNaCa consortium has recently published a series of training videos showing the preparation of samples and running of magnetic nanoparticle hyperthermia experiments.
The first video shows how phantom samples are prepared. Phantom samples possess physiochemical features similar to human tissue and serve as test samples to perform real condition evaluation. Depending on its concentration, agarose gel may imitate either soft tissue (below 2 mg/mL) or hard tissue (above 4 mg/mL).
The second video shows how ex-vivo samples are prepared. Ex-vivo samples comprise of animal tissues together with magnetic nanohybrids, which are used to check the distribution and performance of the magnetic nanohybrids under realistic conditions prior to in-vitro studies.
The third video shows how a typical magnetic particle hyperthermia experiment is run on a liquid suspension containing magnetic nanohybrids.
In the final video, a real-time thermal mapping is shown for magnetic nanohybrids - prepared in the MaNaCa project - subjected to an alternating magnetic field. When the temperature rise exceeds 41 degrees centigrade, the systems are very promising as magnetic heat mediators in modern cancer treatments. Credit to N. Königstein, M. Felek, M. Spasova, and U. Wiedwald (University Duisburg-Essen).